This Week in Science

Mark Aldenderfer, H. Jesse Smith, Brent Grocholski, Ifor Williams, Laura M. Zahn, Sacha Vignieri, Phil Szuromi, Gemma Alderton, Valda Vinson, Marc S. Lavine, Caroline Ash, Wei Wong (+7 others)
2020 Science  
that the vertebrate pituitary arises through interactions of an ancestral endodermal protopituitary with newly evolved placodal ectoderm. -BAP Science, this issue p. 463 NEURODEGENERATION Detecting toxic protein Spinocerebellar ataxia type 3 (SCA3) is a neurodegenerative disorder caused by CAG trinucleotide repeat expansion in the ataxin-3 gene (ATXN3). Reducing the toxic polyglutamine ATXN3 protein might be an effective strategy for treating the disease, and identification of pharmacodynamic
more » ... rkers would facilitate the assessment of potential therapies. Prudencio et al. showed that the toxic protein could be detected in cerebrospinal fluid
doi:10.1126/science.2020.370.6515.twis fatcat:6qnwa53conghlittvuuq2en2ve