Stents farmacológicos para o tratamento de coronárias de fino calibre: experiência muito tardia (até 7 anos) do Registro DESIRE

Ederlon Ferreira Nogueira, Amanda G. M. R. Sousa, J. Ribamar Costa Jr., Adriana Moreira, Ricardo Costa, Galo Maldonado, Cantídio Campos, Manuel Cano, J. Eduardo Sousa
2010 Revista Brasileira de Cardiologia Invasiva  
Drug Eluting Stents for the Treatment of Small Vessels: Very Late Experience (Up to 7 Years) of the DESIRE Registry Background: In this study, we sought to evaluate the clinical outcomes of patients with coronary lesions in small vessels in a cohort of real world patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stents (DES). consecutive patients from the DESIRE Registry (Drug Eluting Stents In The Real World), with 1,683 lesions in small vessels (< 2.5 mm in
more » ... r) were consecutively submitted to elective or emergency PCI, with 1,818 DES (Cypher TM , 89%; Taxus TM , 7.5%; Xience V TM /Promus TM , 3%; Endeavor, 0.33%; Biomatrix TM , 0.2%) and included in this study. The clinical follow-up of up to 7 years (median, 2.8 years) was completed for 98%, and was obtained at 1, 6, 12 months and then annually. Our objective was to determine the rates of major cardiac events (MACE) during clinical follow-up. Results: Mean age was 64.5 ± 11.7 years, with a prevalence of male patients (76.7%). Diabetes mellitus was observed in 31.6% of the cases and 9.8% had chronic renal failure. Left anterior descending artery was the most frequent vessel treated (43.4%) and two-thirds of the lesions were complex lesions (B2/C). Angiographic success was obtained in 98.8% of the cases. The rate of MACE was 12.8% during followup with 4.5% of cardiac death, 4.2% of acute myocardial infarction, 4.5% of repeat target lesion revascularization and 1.5% of stent thrombosis. Conclusion: In the DESIRE Registry, the use of DES to treat small vessels in non-selected patients was associated with excellent early and late outcomes and low thrombosis rates.
doi:10.1590/s2179-83972010000300010 fatcat:uxdwzw675rcj7drmsmjv7zdiiq