Topology-Matching Design of an Influenza-Neutralizing Spiky Nanoparticle-Based Inhibitor with a Dual Mode of Action

Chuanxiong Nie, Badri Parshad, Sumati Bhatia, Chong Cheng, Marlena Stadtmüller, Alexander Oehrl, Yannic Kerkhoff, Thorsten Wolff, Rainer Haag, Universitätsbibliothek Der FU Berlin
In this study, we demonstrate the concept of "topology-matching design" for virus inhibitors. With the current knowledge of influenzaA virus (IAV), we designed a nanoparticle-based inhibitor (nano-inhibitor) that has a matched nanotopology to IAV virions and shows heteromultivalent inhibitory effects on hemagglutinin and neuraminidase. The synthesized nano-inhibitor can neutralize the viral particle extracellularly and block its attachment and entry to the host cells. The virus replication was
more » ... ignificantly reduced by 6 orders of magnitude in the presence of the reverse designed nano-inhibitors. Even when used 24hours after the infection, more than 99.999% inhibition is still achieved, which indicates such a nano-inhibitor might be a potent antiviral for the treatment of influenza infection.
doi:10.17169/refubium-28393 fatcat:gv4nxwbkxvalvczc5gt4cfofsi