Benzimidazoles derivatives with (2-{6-Chloro-5-nitro-1-[2-(1H-tetrazol-5-yl) biphenyl-4-ylmethyl] 1H-benzoimidazol-2-yl}-phenyl)-(substituted-benzylidene)-amine with potential angiotensin II receptor antagonists as antihypertensive activity

Mukesh C Sharma, Dharm V. Kohli, Smita Sharma
2010 International Journal of Drug Delivery  
In this study we have synthesized some Benzimidazole derivatives biphenyl-4-ylmethyl] 1Hbenzoimidazol-2-yl}-phenyl)-(Substituted-benzylidene)-amine and screened for their antihypertensive activity. 4-chloro-o-Phenylenediamine was condensed with anthranilic acid in presence of Polyphosphoric acid and different aryl aldehydes compounds with biphenyl tetrazole ring. The presence of specific functional group were analysed by IR spectroscopy, The determination of structure for the synthesized
more » ... ds by NMR and Mass spectroscopy 13 C NMR, 1 H NMR, FAB Mass. All the synthesized compounds showed significant antihypertensive activity.
doi:10.5138/ijdd.2010.0975.0215.02033 fatcat:z7nri5u3nfcg7axrky3jazfchy