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Treponemal infection specifically enhances node T-cell regulation of macrophage activity
Infection and Immunity
Hamsters experimentally inoculated in the inguinal region with Treponema pallidum subsp. endemicum develop considerable pathology at that site. We examined the cell populations from these inguinal lymph nodes to determine their intercellular responses to infection. In vitro, syphilitic-node T cells markedly suppressed C3b receptor-mediated ingestion (C3bMI) in syphilitic macrophages derived from sites both proximal and distal to the inoculation. This activity was more pronounced when node Tdoi:10.1128/iai.54.1.21-27.1986 fatcat:2zhtbdpugbgddjkklnaq65rgge