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A B S T R A C T COPASI is software used for the creation, modification, simulation and computational analysis of kinetic models in various fields. It is open-source, available for all major platforms and provides a user-friendly graphical user interface, but is also controllable via the command line and scripting languages. These are likely reasons for its wide acceptance. We begin this review with a short introduction describing the general approaches and techniques used in computationaldoi:10.1016/j.jbiotec.2017.06.1200 pmid:28655634 pmcid:PMC5623632 fatcat:uebyrccn6rfhpnrj4sx6o3dmai