An optimized polyamine moiety boosts the potency of human type II topoisomerase poisons as quantified by comparative analysis centered on the clinical candidate F14512

Giulia Palermo, Elirosa Minniti, Maria Laura Greco, Laura Riccardi, Elena Simoni, Marino Convertino, Chiara Marchetti, Michela Rosini, Claudia Sissi, Anna Minarini, Marco De Vivo
2015 Chemical Communications  
Computational–experimental analyses explain F14512's boosted potency as a topoII poison.
doi:10.1039/c5cc05065k pmid:26234198 fatcat:gpncee5jxbffnganfv5clqf5oe