Shaping the Trans-Scale Properties of Schizophrenia via Cerebral Alterations on Magnetic Resonance Imaging and Single-Nucleotide Polymorphisms of Coding and Non-Coding Regions

Shu-Wan Zhao, Xian Xu, Xian-Yang Wang, Tian-Cai Yan, Yang Cao, Qing-Hong Yan, Kun Chen, Yin-Chuan Jin, Ya-Hong Zhang, Hong Yin, Long-Biao Cui
2021 Frontiers in Human Neuroscience  
Schizophrenia is a complex mental illness with genetic heterogeneity, which is often accompanied by alterations in brain structure and function. The neurobiological mechanism of schizophrenia associated with heredity remains unknown. Recently, the development of trans-scale and multi-omics methods that integrate gene and imaging information sheds new light on the nature of schizophrenia. In this article, we summarized the results of brain structural and functional changes related to the
more » ... single-nucleotide polymorphisms (SNPs) in the past decade, and the SNPs were divided into non-coding regions and coding regions, respectively. It is hoped that the relationship between SNPs and cerebral alterations can be displayed more clearly and intuitively, so as to provide fresh approaches for the discovery of potential biomarkers and the development of clinical accurate individualized treatment decision-making.
doi:10.3389/fnhum.2021.720239 pmid:34566604 pmcid:PMC8458928 fatcat:iqjwhqd4j5bo3d55wofw3nlmhi