Biochemical, microbiological and clinical effects of Levonorgestrel-Releasing Intrauterine System (LNG-IUS) on the uterine cervix environment

Thais Costa Coelho de Souza, Paulo Cesar Giraldo, Guilherme Lindman Henrique, Elaine A. L. Garcia, Michelle G. Discacciati, Rose L. Amaral, Rogério B. Machado, ILZA MARIA URBANO MONTEIRO, José M. Sanches
2017 XXV Congresso de Iniciação Científica da Unicamp   unpublished
This study was conducted to evaluate endocervical environment in women using Levonorgestrel-Releasing Intrauterine System (LNG-SIU). The study enrolled 60 women (aged 21 to 52), who had an LNG-IUS inserted in the Family Planning Clinic of UNICAMP, from May 2016 to December 2016. All the subjects were submitted to a specular examination to collect sample for evaluation of the endocervical: pH, microbiota, inflammation and cell dysplasia, using Gram-stained bacteriscopy and Pap-smears before and
more » ... -smears before and after two months of the LNG-IUS insertion. Clinical findings (inflammation, discharge and ectopy of the cervix) were observed by colposcopy. The study showed a significative increase of the endocervical pH and the number of neutrophils, but not of the ectopy size and the endocervical mucus amount. It can be concluded that LNG-IUS promotes biochemicals and cellular changes but not clinical or microbiological alterations in the endocervical environment.
doi:10.19146/pibic-2017-78267 fatcat:7p5ispnszvccjf6nntw2bbu5xa