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Exosomes are small vesicles (60±100 nm) secreted by various cell types upon the fusion of endosomal compartments with the plasma membrane. Exosomes from antigen-presenting cells (APC), such as B lymphocytes and dendritic cells (DC), bear MHC class II molecules. In addition, the injection of DC-derived exosomes was reported to elicit potent T cell responses in vivo. Here, we analyzed the activation of speci®c T cells by MHC class II-bearing exosomes in vitro. The rat mast cell line, RBL-2H3, wasdoi:10.1093/intimm/dxf048 pmid:12096030 fatcat:bhl5cfouxfeczhbb3u4nplcwsq