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Nicotine blocks apomorphine-induced disruption of prepulse inhibition of the acoustic startle in rats: possible involvement of central nicotinicα7receptors
2004
British Journal of Pharmacology
1 Nicotine has been reported to normalize deficits in auditory sensory gating in the cases of schizophrenia, suggesting an involvement of nicotinic acetylcholine receptors in attentional abnormalities. However, the mechanism remains unclear. The present study investigated the effects of nicotine on the disruption of prepulse inhibition (PPI) of the acoustic startle response induced by apomorphine or phencyclidine in rats. 2 Over the dose range tested, nicotine (0.05-1 mg kg À1 , s.c.) did not
doi:10.1038/sj.bjp.0705855
pmid:15197106
pmcid:PMC1575066
fatcat:lfpmjrdupvc3bmm34qsy7drevm