Compromised Mitochondrial Protein Import Acts as a Signal for UPRmt

Sttphane G. Rolland, Sandra Schneid, Melanie Schwarz, Elisabeth Rackles, Christian Fischer, Simon Haeussler, Saroj Regmi, Assa Yeroslaviz, Bianca Habermann, Dejana Mokranjac, Eric Lambie, Barbara Conrandt
2018 Social Science Research Network  
Graphical Abstract Highlights d Impairment of most, but not all, mitochondrial processes causes UPR mt d Conditions inducing UPR mt lead to a decrease in mitochondrial membrane potential d Decrease in mitochondrial membrane potential acts as a signal that triggers UPR mt d The MTS of ATFS-1 acts as a sensor for decreased mitochondrial membrane potential
doi:10.2139/ssrn.3209462 fatcat:prtpnj6kqvh3todtq74xl4vene