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Effect of Substitution on the Antimycobacterial Activity of 2-(Substituted benzyl)sulfanyl Benzimidazoles, Benzoxazoles, and Benzothiazoles—A Quantitative Structure–Activity Relationship Study
Chemical and pharmaceutical bulletin
Experimental Chemistry The synthesis and structural features of 2-(subst. benzyl)sulfanyl benzimidazole (BIM), 5) 5-methylbenzimidazole (5-Me-BIM), 6) benzoxazole (BOZ), 7) and some benzothiazole (BTZ) 8 ) derivatives (benzazoles) have already been published. Biology The antimycobacterial activity of the model compounds was evaluated in vitro against Mycobacterium tuberculosis CNCTC My 331/88, Mycobacterium kansasii CNCTC My 235/80, Mycobacterium kansasii 6509/96 and Mycobacterium avium CNCTCdoi:10.1248/cpb.59.179 pmid:21297296 fatcat:2vkfvblimrbfxeepzct6xjjxjy