Using concepts in literature-based discovery: Simulating Swanson's Raynaud-fish oil and migraine-magnesium discoveries

Marc Weeber, Henny Klein, Lolkje T.W. de Jong-van den Berg, Rein Vos
2001 Journal of the American Society for Information Science and Technology  
Literature-based discovery has resulted in new knowledge. In the biomedical context, Don R. Swanson has generated several literature-based hypotheses that have been corroborated experimentally and clinically. In this paper, we propose a two-step model of the discovery process in which hypotheses are generated and subsequently tested. We have implemented this model in a Natural Language Processing system that uses biomedical Unified Medical Language System (UMLS) concepts as its unit of
more » ... We use the semantic information that is provided with these concepts as a powerful filter to successfully simulate Swanson's discoveries of connecting Raynaud's disease with fish oil and migraine with a magnesium deficiency.
doi:10.1002/asi.1104 fatcat:oxhbusz6efe4fn4j3muwd33nwa