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Defensin-driven viral evolution
2020
PLoS Pathogens
Enteric alpha-defensins are potent effectors of innate immunity that are abundantly expressed in the small intestine. Certain enteric bacteria and viruses are resistant to defensins and even appropriate them to enhance infection despite neutralization of closely related microbes. We therefore hypothesized that defensins impose selective pressure during fecal-oral transmission. Upon passaging a defensin-sensitive serotype of adenovirus in the presence of a human defensin, mutations in the major
doi:10.1371/journal.ppat.1009018
pmid:33232373
fatcat:52jgduaogng3bctjgxgesbvop4