Clinical epigenetics settings for cancer and cardiovascular diseases: real-life applications of network medicine at the bedside

Federica Sarno, the International Network Medicine Consortium, Giuditta Benincasa, Markus List, Albert-Lazlo Barabasi, Jan Baumbach, Fortunato Ciardiello, Sebastiano Filetti, Kimberly Glass, Joseph Loscalzo, Cinzia Marchese, Bradley A. Maron (+7 others)
2021 Clinical Epigenetics  
AbstractDespite impressive efforts invested in epigenetic research in the last 50 years, clinical applications are still lacking. Only a few university hospital centers currently use epigenetic biomarkers at the bedside. Moreover, the overall concept of precision medicine is not widely recognized in routine medical practice and the reductionist approach remains predominant in treating patients affected by major diseases such as cancer and cardiovascular diseases. By its' very nature,
more » ... is integrative of genetic networks. The study of epigenetic biomarkers has led to the identification of numerous drugs with an increasingly significant role in clinical therapy especially of cancer patients. Here, we provide an overview of clinical epigenetics within the context of network analysis. We illustrate achievements to date and discuss how we can move from traditional medicine into the era of network medicine (NM), where pathway-informed molecular diagnostics will allow treatment selection following the paradigm of precision medicine.
doi:10.1186/s13148-021-01047-z pmid:33785068 pmcid:PMC8010949 fatcat:vojcp6avfrdfzi2vero5iaznji