UNMARY Female ICR inicc \\, CTe infected \\, ith I{SV-I and HSV-2 by insetting a cotton pellet soaked in \, Iral solution (10'~' FFUlml) into the \, agina. The appcarance of giant cells and formation of intranuclear inclusions were detected in the epithclial layer of the uterus 24 h after intra\, aginal inoculation. These histopathological changes wei'c pronounced 3 to 4 days after \, irus inoculation and then gradually disappeared in the next fcw days Results of fluorescent antibody, studies

more »

... the appearance of vii. al antigens in infocied uterine tissues and results of \, iral infectivity titrations of emulsified samples of infectcd uteri coincided wall with the histopathological observations on the gene-Tai collrsc of \, Irus infection Thc ticgi'ce of histopathological involvcmcnt caused by HSV-I \\, as somewhat less than tltat causcd by HSV-2, and the laboratory strains of HS\'-I so far examin-CLI (HF and Allyama) \\, CTe found to be especially \\, cakly pathogenic.