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Independent component analysis as a model-free approach for the detection of BOLD changes related to epileptic spikes: A simulation study
2009
Human Brain Mapping
EEG-fMRI in epileptic patients is commonly analyzed using the general linear model (GLM), which assumes a known hemodynamic response function (HRF) to epileptic spikes in the EEG. In contrast, independent component analysis (ICA) can extract Blood-Oxygenation Level Dependent (BOLD) responses without imposing constraints on the HRF. This technique was evaluated on data generated by superimposing artificial responses on real background fMRI signals. Simulations were run using a wide range of EEG
doi:10.1002/hbm.20647
pmid:18726909
pmcid:PMC3792083
fatcat:vmnoa436djgdjnzwdp32qnk5t4