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Differential Compartmentalization and Distinct Functions of GABAB Receptor Variants
2006
Neuron
GABA B receptors are the G protein-coupled receptors for the main inhibitory neurotransmitter in the brain, g-aminobutyric acid (GABA). Molecular diversity in the GABA B system arises from the GABA B1a and GABA B1b subunit isoforms that solely differ in their ectodomains by a pair of sushi repeats that is unique to GABA B1a . Using a combined genetic, physiological, and morphological approach, we now demonstrate that GABA B1 isoforms localize to distinct synaptic sites and convey separate
doi:10.1016/j.neuron.2006.04.014
pmid:16701209
pmcid:PMC3531664
fatcat:n6qzhw4zbvbcrkbmct4mzx66q4