Absence of Association between Organic Solvent Exposure and Risk of Chronic Renal Failure: A Nationwide Population-Based Case-Control Study

C. M. Fored
2004 Journal of the American Society of Nephrology  
Exposure to organic solvents has been suggested to cause or exacerbate renal disease, but methodologic concerns regarding previous studies preclude firm conclusions. We examined the role of organic solvents in a population-based case-control study of early-stage chronic renal failure (CRF). All native Swedish residents aged 18 to 74 yr, living in Sweden between May 1996 and May 1998, formed the source population. Incident cases of CRF in a pre-uremic stage (n ϭ 926) and control subjects (n ϭ
more » ... ol subjects (n ϭ 998), randomly selected from the study base, underwent personal interviews that included a detailed occupational history. Expert rating by a certified occupational hygienist was used to assess organic solvent exposure intensity and duration. Relative risks were estimated by odds ratios (OR) in logistic regression models, with adjustment for potentially important covariates. The overall risk for CRF among subjects
doi:10.1097/01.asn.0000103872.60993.06 pmid:14694171 fatcat:5sbnim2dqzh3jebnzvjx2mache