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There are numerous microorganisms in nature capable of synthesizing diverse useful compounds; however, these natural microorganisms are generally inefficient in the production of target products on an industrial scale, relative to either chemical synthesis or extraction methods. To achieve industrial production of useful compounds, these natural microorganisms must undergo a certain degree of mutation or effective fine-tuning strategies. This review describes how to achieve an ideal metabolicdoi:10.1016/j.synbio.2020.05.002 pmid:32542205 pmcid:PMC7283098 fatcat:kv5fdpafibgsxocge6hlkyznau