Fairness, low latency, and high throughput with low energy consumption are desired attributes for Medium Access Control (MAC) protocols. The IEEE 802.15.4 standard defines the MAC and physical (PHY) layers standard for IPv6 over Low power Personal Area Network (6LoWPAN). When nonappropriate parameter setting is used, the default MAC parameters generate excessive collisions, packet losses, and high latency under high traffic when a large number of 6LoWPAN nodes being deployed. A search of the

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... erature revealed few studies which investigate the impact of optimising these parameters to achieve high throughput with minimum latency. This paper proposes a new intelligent approach to select the optimal 6LoWPAN MAC layer parameters set, the introduced mechanism depends on Artificial Neural Networks (ANN), Genetic Algorithm (GA) or Particles Swarm Optimisation (PSO) to select and validate the optimised MAC parameters. The obtained simulation results showed that utilising the optimal MAC parameters improved 6LoWPAN network throughput by 52-63% and reduced the endto-end delay by 54-65% in which the enhancement percentage depends on the number of deployed sensor nodes in the network.