L-Proline-functionalized magnetic nanocomposite: a green magnetic nanocatalyst for efficient synthesis of imidazo[1,2-a]pyridines

Ali Maleki, Razieh Firouzi Haji
2017 Proceedings of The 21st International Electronic Conference on Synthetic Organic Chemistry   unpublished
In this work, an efficient method for the immobilization of L-proline on magnetic nanoparticles was offered and evaluated as a recoverable magnetic organocatalyst for synthesis of 3aminoimmidazo[1,2-a]pyridine from 2-aminopyridine, aromatic aldehyde and trimethylsilyl cyanide (TMSCN). This magnetic organocatalyst proved to be effective and provided the products in high to excellent yield at room temperature. Moreover, the catalyst could be easily recovered by facile separation by magnetic
more » ... and recycled for five times without significant loss of its catalytic activity. The benefits of this study are simplicity, nontoxicity, low cost, simple workup, and an environmentally benign nature.
doi:10.3390/ecsoc-21-04720 fatcat:errnwwxxondd7d5wdelgub6zqy