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OUP accepted manuscript
2019
Nucleic Acids Research
Estrogen receptor ␣ (ER␣) is an enhancer activating transcription factor, a key driver of breast cancer and a main target for cancer therapy. ER␣mediated gene regulation requires proper chromatinconformation to facilitate interactions between ER␣bound enhancers and their target promoters. A major determinant of chromatin structure is the CCCTCbinding factor (CTCF), that dimerizes and together with cohesin stabilizes chromatin loops and forms the boundaries of topologically associated domains.
doi:10.1093/nar/gkz675
fatcat:sdaa677vfnemzekvy7hkdaq3c4