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Applications of high-speed counter-current chromatography (HSCCC) for the separations of antibiotics, cyclosporins and isoflavones, by a marine Micromonospora and macrolides including tacrolimus, ascomycin, and dihydroFk-506 are described. The application of silver ion HSCCC technique in the separation of tacrolimus from its components is also described.doi:10.1093/chromsci/47.5.354 pmid:19476702 fatcat:oeojikgbozgvpaiu7ivg76kivi