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RAD51 Protein ATP Cap Regulates Nucleoprotein Filament Stability
2012
RAD51 mediates homologous recombination by forming an active DNA nucleoprotein filament (NPF). A conserved aspartate that forms a salt bridge with the ATP γ-phosphate is found at the nucleotide-binding interface between RAD51 subunits of the NPF known as the ATP cap. The salt bridge accounts for the nonphysiological cation(s) required to fully activate the RAD51 NPF. In contrast, RecA homologs and most RAD51 paralogs contain a conserved lysine at the analogous structural position. We
doi:10.17615/2qvs-d124
fatcat:vgi2cml37vfoxoayi4lgpfp62u