Deletion or substitution of conserved amino acid residues at the tip of the domain IV of Tet(O) impairs tetracycline resistance

Oindrila Mukherjee
Resistance to tetracycline (Tc), an inhibitor of protein synthesis, decreases its effectiveness for the treatment of bacterial infections. Tc resistance (Tc R ) can be mediated by the ribosomal protection protein, Tet(O), which was first reported in Campylobacter jejuni, a cause of bacterial diarrhea worldwide. Tet(O) confers Tc R by mediating Tc release from 70S ribosomes, thus restoring protein synthesis.
doi:10.7939/r3k43n fatcat:euexqztkyfc4pm25etzqb376gi