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Deletion or substitution of conserved amino acid residues at the tip of the domain IV of Tet(O) impairs tetracycline resistance
2011
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Resistance to tetracycline (Tc), an inhibitor of protein synthesis, decreases its effectiveness for the treatment of bacterial infections. Tc resistance (Tc R ) can be mediated by the ribosomal protection protein, Tet(O), which was first reported in Campylobacter jejuni, a cause of bacterial diarrhea worldwide. Tet(O) confers Tc R by mediating Tc release from 70S ribosomes, thus restoring protein synthesis.
doi:10.7939/r3k43n
fatcat:euexqztkyfc4pm25etzqb376gi