Experimental and analytical tools for rapid development of digital imaging-based elasto-tomography technology [article]

Hina Muhammad Ismail, University Of Canterbury
2018
Breast cancer is the second most common cancer in the world and has the highest cancer mortality rate in women. Presently, 1 of every 4 women carry an increased risk of breast cancer, of which, 6% are below the minimum screening age of 45. Early detection via regular screening not only reduces mortality rates, but also decreases overall treatment expenditure. X-ray mammography is the clinical standard breast cancer screening technique. However, due to significant limitations, such as
more » ... such as unacceptable rates of false positive and false negative results, exposure to ionizing radiation, and discomfort and pain due to the compression of the breast it is not recommended for women under 45 years of age. These women also often have denser breast tissues, which further reduce mammography efficacy and diagnostic capability. Digital imaged elasto-tomography (DIET) has been developed to overcome some of the limitations of current techniques and mammography in particular. The digital imaged elasto-tomography (DIET) concept is based on non-invasive, pain-free, vibration based analysis of local tissue stiffness, a form of elastographic reconstruction from actuation motion. This technique enables early detection of breast cancer, as it is not restricted in the ages of women who could utilize it for screening. Thus, combined with effective treatment, it could reduce mortality, particularly for younger women. More specifically, recent analysis showing annual mammography down to 40 years of age would save many more lives than current screening, indicating a system like DIET, safely offering screening to any age, could significantly improve breast cancer mortality. DIET is a novel method and technology, but is not yet at a stage suitable for a large randomised clinical trial. However, its development could be significantly enhanced by a series of tools to improve the speed and repeatability of DIET technology development. Currently, DIET is developed primary by executing pilot clinical testing of human volunteers. This experimental appr [...]
doi:10.26021/1737 fatcat:3ib4uncwkbgkrgopvjefpdcism