In the next year, 2022, we are planning to return toour in-person activities. After a long period in remotework, this brings us great breath and hope for betterdays. Mass vaccination is a gold medal won despitemany difficulties and obscure obstacles, in oppositionto our principle of taking science above beliefs, emptyopinions, without ambiguity, and fake news.This issue of our journal crowns this hopeful returnwith interesting articles such as the epidemiologicalstudy of hypertensive elderly

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... ple, risk factors associatedwith many morbidities including respiratorysyndrome caused by viruses; association betweensmoking and COVID 19, a subject always highlightedby the current and importance of the topic; well-designedprotocols for clinical studies with vibrationexercises; infectious diseases in intensive care units, amatter of extreme relevance, given the exponentialincrease in these patients caused by the pandemic;in addition to studies in genetics and biochemistry,important analytical parameters in studies of cancerand metabolic alterations related to smoking, a greatepidemic of our times.Finally, review articles with relevant topics intropical infectious disease and cancer. We close with aclinical case to sharpen our reasoning and bring a lightand stimulating learning experience.A good read for everyone, happy 2022.