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Antiparasitic Effects of the Intra-Golgi Transport Inhibitor Megalomicin
Antimicrobial Agents and Chemotherapy
The macrolide antibiotic megalomicin (MGM) has been shown to inhibit vesicular transport between the medial- and trans-Golgi, resulting in the undersialylation of cellular proteins (P. Bonay, S. Munro, M. Fresno, and B. Alarcón, J. Biol. Chem. 271:3719–3726, 1996). Due to the effects of MGM on the Golgi and on the replication of enveloped viruses, we decided to test whether it has any antiparasitic activity. The results showed that MGM has potent activity against the epimastigote stage ofdoi:10.1128/aac.42.10.2668 fatcat:dz2gep4bvffmno5bagvyffv4ma