Sexual Functioning in Chronically Depressed Patients Treated With SSRI Antidepressants: A Pilot Study

Lisa A. Piazza, John C. Markowitz, James H. Kocsis, Andrew C. Leon, Laura Portera, Nina L. Miller, Douglas Adler
1997 American Journal of Psychiatry  
Objective: This prospective study assessed changes in depression and sexual functioning in chronically depressed men and women during treatment with selective serotonin reuptake inhibitors (SSRIs). Method: Twenty-five subjects (14 women, 11 men) with DSM-III-R dysthymia, chronic major depression, or double depression were administered the Arizona Sexual Experience Scale and the Hamilton Depression Rating Scale before and after 6 weeks of treatment with sertraline or paroxetine. Results: As
more » ... red by scores on the Arizona Sexual Experience Scale, desire, psychological arousal, and overall sexual functioning significantly improved in women; orgasm delay, orgasm satisfaction, and overall sexual functioning significantly worsened in men. Conclusions: This study suggests that after SSRI treatment, difficulties with desire and psychological arousal in depressed women tend to remit, whereas in men orgasmic dysfunction appears to be a side effect of medication.
doi:10.1176/ajp.154.12.1757 pmid:9396959 fatcat:ilrcjb7hpfg5be73wib3rnakcq