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Mammalian cells coordinately regulate their gene expression programmes to ensure appropriate responses to stimuli. While transcriptional events provide an important level of gene expression regulation, modulation of messenger RNA (mRNA) decay provides an additional critical regulatory step. Much of the current knowledge of regulated mRNA decay comes from investigations of cytokine and other early response genes involved in inflammation and immunity. Recent genome-wide measurements of mRNA decaydoi:10.1093/bfgp/3.2.112 pmid:15355594 fatcat:vndei4qh5rdnvcgip55r6annge