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Effect of neutral mutation on HIV-1 drug resistance in highly active antiretroviral therapy
Scientific Research and Essays
Human immunodeficiency virus 1 (HIV-1) drug resistance is a grave problem in highly active antiretroviral therapy (HAART) and neutral mutation is an important factor in the evolution of HIV-1. We consider the process of HIV-1 quasispecies transition in HAART to be transformation among three viral phenotypes: wild-type HIV-1, neutral-type HIV-1 and resistant-type HIV-1. A new model is proposed to study the transition dynamics of resistant-type HIV-1 induced by neutral mutation. The colonizeddoi:10.5897/sre11.1693 fatcat:6oyv2dyi55guvnlruc5bxu4qqe