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Three invariant Hi-C interaction patterns: applications to genome assembly
[article]
2018
bioRxiv
pre-print
Assembly of reference-quality genomes from next-generation sequencing data is a key challenge in genomics. Recently, we and others have shown that Hi-C data can be used to address several outstanding challenges in the field of genome assembly. This principle has since been developed in academia and industry, and has been used in the assembly of several major genomes. In this paper, we explore the central principles underlying Hi-C-based assembly approaches, by quantitatively defining and
doi:10.1101/306076
fatcat:44fy7q2p55gyjmyf4m6eieswsy