The Impact of Perturbing Dynamic Amino Acid Networks in a (β/α)8 Barrel Enzyme

Kathleen F. O'Rourke, Jennifer M. Axe, Nicole E. Kerstetter, David D. Boehr
2015 Biophysical Journal  
The synaptic vesicle protein Synaptotagmin I is the calcium ion sensor for neurotransmitter release. Synaptotagmins are comprised of C2 domains, calcium ion dependent, membrane-binding domains. They contain multiple C2 domains and all C2 domains are tethered to the membrane. Our recent work
doi:10.1016/j.bpj.2014.11.2897 fatcat:5ufeea6m3ncnzczphzvtezqeoi