Multi-scale Agent-based Models in Immunology. A Short Review

Marzio Pennisi
2021 International Conference on Information and Knowledge Management  
In the drug discovery pipeline, the lack of multi-scale modeling approaches able of taking into account the observation of an immunological phenomenon from the molecular to the tissue/organism levels represents a big issue. In this scenario, agent-based models can partially make up for this issue allowing them to accurately describe all the interactions that occur at the cellular level and showing the phenomenon at the tissue/organ level thanks to their capability of producing emergent global
more » ... haviors. This short review will present some of these agent-based approaches developed for the simulation of diseases and the relative immune system response that also try to explicitly include molecular-level aspects such as internal cell behavior or receptor binding, for a more real and complete representation of the immunological phenomena under examination.
dblp:conf/cikm/Pennisi21 fatcat:oaduhxgzfvhnjdbvxllt7bbvx4