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Melatonin have diverse physiological functions, including the control of circadian rhythms, sleep regulation, enhancement of immunological functioning, free radical scavenging and antioxidant effects, inhibition of oncogenesis, mood regulation, vasoregulation, regulation of seasonal reproductive activity and analgesia. Melatonin also have several actions within the central nervous system and in the pathophysiology of headaches, which include an anti-inflammatory effect, toxic free radicaldoi:10.48208/headachemed.2012.14 fatcat:a7orbqo54zghhjmrhri4qjil7y