The aim of the present research work was to investigate the antimicrobial potential of Asparagus racemosus Willd. and Juglans regia L. against certified pathogenic microorganisms; Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella typhi, Staphylococcus aureus and Streptococcus pneumoniae, using agar well diffusion method. Aqueous extract of A. racemosus root was more effective among others and maximum inhibition was observed against S. typhi and E. coli (18 mm at 4

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... ). In case of J. regia, bark acetone extract was found most effective with highest activity observed against S. aureus (24 mm at 4 mg/ml). The minimum concentration of 0.4 mg in case of (A. racemosus) and 0.6 mg for (J. regia) were required to inhibit the growth of P. aeruginosa and S. aureus, respectively. Based on the initial screening results with A. racemosus and J. regia plant extracts, it can be concluded that they have the potential to be used as alternate to synthetic medicines bu t only after intensive research a nd development a nd clinical trials. Moreover, if successful, this will provide a resource which is relatively cheaper, safer to use and with less or no side effects.