lAsparaginase Encapsulation into Asymmetric Permeable Polymersomes [component]

This work reports for the encapsulation of L-asparaginase, an anticancer enzyme into hybrid PMPC25-PDPA70/ PEO16-PBO22 asymmetric polymersomes previously developed by our group, with loading capacities with over than 800 molecules per vesicle. Enzyme-loaded polymersomes show permeability and capacity to hydrolyze L-asparagine, which is essential to cancer cells. The nanoreactors proposed in this work can potentially be used in further studies to develop novel therapeutic alternatives based on L-asparaginase.
doi:10.1021/acsmacrolett.0c00619.s001 fatcat:l5xgspjxyrh37kij4gmbjsdlem