Down's syndrome is one of the common chromosomal abnormalities seen. Also means yes having thyroid dysfunctions would be better than neonatal having thyroid dysfunction. The patients having Down's syndrome are having thyroid dysfunction and the children having down's syndrome are at higher risk to have thyroid dysfunction and these children are having both the hypothyroidism and hyperthyroidism. The present study aims at identifying the thyroid dysfunctions among the patients having Down's

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... ome. : The present study is an observational study which is being conducted in tertiary care hospital from March 2018 to June 2019. In this study 80 neonatal having Down's syndrome were being examined and the thyroid function tests are being performed on the patients for identifying the prevalence of thyroid dysfunction in patients with Down's syndrome. The patients are being selected on the basis of inclusion and exclusion criteria. In the present study it is being found that 56% of the patients were having normal thyroid function and 44% were having abnormal thyroid function. TSH value of the patients having abnormal thyroid function is significantly higher as compared to the patients having normal thyroid function. The mean of FT3 (pg/ml) among the patients having normal and abnormal thyroid function was found to be 2.9±0.4 and 2.5±0.9 respectively and the mean of FT4 (pg/ml) among the patients having normal and abnormal thyroid function was found to be 14.9±8.4 and 2.5±0.9 respectively 13.5±7.9. The study concluded that there is a significant impact of down syndrome on the thyroid function and the patients having down syndrome are at higher risk of thyroid diseases as it is found that the patients having down syndrome are having abnormal thyroid function and higher TSH value.