The interconnectedness and complexity of cyber-physical systems (CPSs) provide greater quality of service, productivity, and flexibility. On the other hand, the high levels of interactions, communications, and dependencies within CPSs also increase their vulnerabilities to disruptions and targeted attacks. Disruptions in one part of a CPS can propagate to another part, eventually compromising the entire CPS if protective mechanisms and preparations are insufficient. This challenge is addressed

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... n this work with the Collaborative Response to Disruption Propagation with Established Lines of Collaboration (CRDP/ESLOC) model. The CRDP/ESLOC model simulates the effects of disruption propagation on a CPS and provides informatics on the disruptions' behaviors. The CRDP/ESLOC model also analyzes the possible strategic decisions of allocating prevention resources and recovery resources to contain and mitigate the disruptions, and recover the CPS for continuity of service. The new disruption propagation informatics and protocols, categorized as centrality-based and coverage-based, are simulated and validated with a network model based on an industrial CPS. The experiment shows that coverage-based informatics and protocols provide higher CPS prevention and recovery resilience, and thus, should be further developed in future work. Abstract The interconnectedness and complexity of cyber-physical systems (CPSs) provide greater quality of service, productivity, and flexibility. On the other hand, the high levels of interactions, communications, and dependencies within CPSs also increase their vulnerabilities to disruptions and targeted attacks. Disruptions in one part of a CPS can propagate to another part, eventually compromising the entire CPS if protective mechanisms and preparations are insufficient. This challenge is addressed in this work with the Collaborative Response to Disruption Propagation with Established Lines of Collaboration (CRDP/ESLOC) model. The CRDP/ESLOC model simulates the effects of disruption propagation on a CPS and provides informatics on the disruptions' behaviors. The CRDP/ESLOC model also analyzes the possible strategic decisions of allocating prevention resources and recovery resources to contain and mitigate the disruptions, and recover the CPS for continuity of service. The new disruption propagation informatics and protocols, categorized as centrality-based and coverage-based, are simulated and validated with a network model based on an industrial CPS. The experiment shows that coverage-based informatics and protocols provide higher CPS prevention and recovery resilience, and thus, should be further developed in future work.