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Both alcohol and HIV (human immunodeficiency virus) can affect the structure and function of the central nervous system. What they have in common is that the white matter of the brain is principally affected, and the direct neuronal injury does not appear to be a consequence of either HIV infection or alcohol use. There is evidence that the cognitive effects of both HIV and alcohol are potentially reversible with treatment or abstinence. There is only limited overlap in terms of the actualdoi:10.2147/nbhiv.s7364 fatcat:7kak2qvx2vcmdor33wbo6yqdti