Metabotropic Glutamate Receptors and Interacting Proteins in Epileptogenesis

Feng Qian, Feng-Ru Tang
2016 Current Neuropharmacology  
Neurotransmitter and receptor systems are involved in different neurological and neuropsychological disorders such as Parkinson's disease, depression, Alzheimer's disease and epilepsy. Recent advances in studies of signal transduction pathways or interacting proteins of neurotransmitter receptor systems suggest that different receptor systems may share the common signal transduction pathways or interacting proteins which may be better therapeutic targets for development of drugs to effectively
more » ... ontrol brain diseases. In this paper, we reviewed metabotropic glutamate receptors (mGluRs) and their related signal transduction pathways or interacting proteins in status epilepticus and temporal lobe epilepsy, and proposed some novel therapeutical drug targets for controlling epilepsy and epileptogenesis.
doi:10.2174/1570159x14666160331142228 pmid:27030135 pmcid:PMC4983745 fatcat:wqwmvarw6zfazlhi7vgyckfk3i