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Acquisition of Stable Inducible Up-Regulation of Nuclear Factor- B by Tumor Necrosis Factor Exposure Confers Increased Radiation Resistance without Increased Transformation in Breast Cancer Cells
Molecular Cancer Research
High-grade breast cancers are better adapted to hypoxia and more resistant to chemotherapy and radiotherapy. Constitutive activation of the transcription factor nuclear factor-KB (NF-KB) increases in breast tumors and in breast cancer cell lines, where it promotes chemoradiation resistance, in part by activation of antiapoptotic genes. The role for up-regulation of NF-KB in breast cancer progression is less clear. Here, we first show that whereas the constitutive activity of NF-KB isdoi:10.1158/1541-7786.mcr-07-0339 pmid:18234964 fatcat:fi4ij2jb6fgbpazs3tabjpp5su