Objective: This study aims to analyze the complications of endoscopic transsphenoidal surgery for pituitary neoplasms. Methods: 326 patients who underwent neuroendoscopic endonasal transsphenoidal surgery at the neurosurgery department of the First Affiliated Hospital of Chongqing Medical University from July 2012 to July 2015 were enrolled in this retrospective analysis. Results: Among the 326 patients, the cases of postoperative hy-ponatremia, diabetes insipidus, hypopituitarism,

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... cerebrospinal fluid leak, meningitis, cranial nerves palsy, epistaxis, sphenoid sinusitis, internal carotid artery injury and residual tumor bleeding respectively are 32 (9.8%), 12 (3.7%), 23 (7.1%), 13 (4.0%), 1 (0.3%), 3 (0.9%), 5 (1.5%), 3 (0.9%), 1 (0.3%) and 1 (0.3%). Conclusion: Endoscopic endonasal transsphenoidal surgery has the considerable total resection rates for pituitary adenomas and preventable postoperative complications.