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Autism excitation-inhibition imbalance linked to brain hyperconnectivity: An analysis based on 657 autistic subjects
[article]
2022
bioRxiv
pre-print
The large heterogeneity in autism spectrum disorder (ASD) is a major drawback for the development of therapies. Here, we apply consensus-subtyping strategies based on functional connectivity patterns to a population of N=657 quality-assured autistic subjects. We found two major subtypes (each divided hierarchically into several minor subtypes): Subtype 1 exhibited hypoconnectivity (less average connectivity than typically developing controls) and subtype 2, hyperconnectivity. The two subtypes
doi:10.1101/2022.07.14.500131
fatcat:dwkp26gq4jhwpfvyctfigjfhmi