6) The pulse is unchanged in myxedema. If thyroid extract is fed, the pressure is lowered and arterial relaxation occurs. (7) Diuresis is produced. Dit. Osborne, in closing the discussion, spoke of the importance of small doses in giving the organic extracts. Large doses, as of the thyroid, may occasion a great deal of injury. He was much impressed, he said, with Dr. Thomson's views on Graves' disease. As a result, he would in the future diminish the nitrogeneous food supply of his patients. As

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... to the effect of mercury, he thought it probably stopped some secretion. He could not but believe still, however, that Graves' disease has a great deal to do with the thyroid gland. Alteratives all stimulate «the thyroid to greater activity. He had hoped that the physiologists would have said something about the origin of the polymorphnuclcar leucocytes of the blood. Recent Literature.