Adaptive Identification of Cortical and Subcortical Imaging Markers of Early Life Stress and Posttraumatic Stress Disorder

Lauren E. Salminen, Rajendra A. Morey, Brandalyn C. Riedel, Neda Jahanshad, Emily L. Dennis, Paul M. Thompson
2019 Journal of Neuroimaging  
Posttraumatic stress disorder (PTSD) is a heterogeneous condition associated with a range of brain imaging abnormalities. Early life stress (ELS) contributes to this heterogeneity, but we do not know how a history of ELS influences traditionally defined brain signatures of PTSD. Here, we used a novel machine learning method - evolving partitions to improve classification (EPIC) - to identify shared and unique structural neuroimaging markers of ELS and PTSD in 97 combat-exposed military veterans.
doi:10.1111/jon.12600 pmid:30714246 pmcid:PMC6571150 fatcat:cp7jew3d6rh7ta3xc3tjpkcdxm