Pathological image classification is of great importance in various biomedical applications, such as for lesion detection, cancer subtype identification, and pathological grading. To this end, this paper proposed a novel classification framework using the multispace image reconstruction inputs and the transfer learning technology. Specifically, a multispace image reconstruction method was first developed to generate a new image containing three channels composed of gradient, gray level

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... nce matrix (GLCM) and local binary pattern (LBP) spaces, respectively. Then, the pretrained VGG-16 net was utilized to extract the high-level semantic features of original images (RGB) and reconstructed images. Subsequently, the long short-term memory (LSTM) layer was used for feature selection and refinement while increasing its discrimination capability. Finally, the classification task was performed via the softmax classifier. Our framework was evaluated on a publicly available microscopy image dataset of IICBU malignant lymphoma. Experimental results demonstrated the performance advantages of our proposed classification framework by comparing with the related works.