Corneal Endothelial Cell Changes after Pars Plana Vitrectomy: Silicone versus Non Silicone Filled Eyes
Zagazig University Medical Journal
The corneal complications of a successful vitreoretinal surgery are not the main interest of the surgeon operating on a difficult retinal detachment. However, the surgeon should pay attention to avoid corneal decompensation. The current study was aimed to evaluate corneal endothelial cell changes in patients undergoing pars plana vitrectomy with and without silicone oil (SO) injection. Methods: This prospective observational study includes 54 eyes divided into two equal groups: silicone-filled
... roup (group one) and saline-filled group (group two). Endothelial cell densities (ECD), coefficient of variation (CV), central corneal thickness (CCT), and percentage of hexagonal cells at the corneal center were measured preoperatively and at the first week, the first month, and the third month postoperatively and compared between the two groups. All data were collected and statistically analyzed using the SPSS program. Results: Three months after PPV, mean ECD in group one and in group two was highly significant (p<0.001) with the main decrease in cell count occurring in the first week postoperatively. However, the difference in the endothelial cell loss between the two groups was clinically insignificant (p=0.18) but more affected in group 1. Conclusions: Pars plana vitrectomy (PPV) was associated with corneal endothelial cell changes which were higher in patients with SO injection than those left saline-filled; however they were statistically insignificant. Silicone oil could be a risk factor for increasing endothelial cell loss after PPV.